Mercedes-Benz
E350
U.S. fuel economy and specifications from the EPA.

Best combined MPG by model year
The highest EPA rating among each year's configurations.
1 configuration.
Rear-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 28
- Engine displacement
- 2.0 L
- Cylinders
- 4
Rear-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 28
- Engine displacement
- 2.0 L
- Cylinders
- 4
Rear-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 28
- Engine displacement
- 2.0 L
- Cylinders
- 4
2025 EPA test-car reference
Engine ratings from the EPA test-car reference.
| Engine rated hp | Displacement | Transmission | Drive |
|---|---|---|---|
| 255 | 2.0 L | Automatic · 9 gears | 2-Wheel Drive, Rear |
Rear-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 26
- Engine displacement
- 2.0 L
- Cylinders
- 4
Rear-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 26
- Engine displacement
- 2.0 L
- Cylinders
- 4
Rear-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 2.0 L
- Cylinders
- 4
Rear-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 26
- Engine displacement
- 2.0 L
- Cylinders
- 4
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 23
- Combined MPG on E85
- 16
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 23
- Combined MPG on E85
- 16
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 24
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 23
- Combined MPG on E85
- 18
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 23
- Combined MPG on E85
- 17
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 20
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 21
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 19
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 19
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 19
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 20
- Engine displacement
- 3.5 L
- Cylinders
- 6