Mercedes-Benz
E350 4matic
U.S. fuel economy and specifications from the EPA.
27Best combined MPG2024 model year
2006–2027Model years19 with EPA ratings
25Rated configurationsDrive, transmission and engine
2–3.5 LEngine sizeDisplacement
Best combined MPG by model year
The highest EPA rating among each year's configurations.
2006 19 MPG
2007 19 MPG
2008 18 MPG
2009 18 MPG
2010 19 MPG
2011 19 MPG
2012 22 MPG
2013 22 MPG
2014 23 MPG
2015 23 MPG
2016 23 MPG
2017 No rating
2018 No rating
2019 No rating
2020 25 MPG
2021 25 MPG
2022 24 MPG
2023 24 MPG
2024 27 MPG
2025 27 MPG
2026 27 MPG
2027 27 MPG
1 configuration.
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 27
- Engine displacement
- 2.0 L
- Cylinders
- 4
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 27
- Engine displacement
- 2.0 L
- Cylinders
- 4
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 27
- Engine displacement
- 2.0 L
- Cylinders
- 4
2025 EPA test-car reference
Engine ratings from the EPA test-car reference.
| Engine rated hp | Displacement | Transmission | Drive |
|---|---|---|---|
| 255 | 2.0 L | Automatic · 9 gears | All Wheel Drive |
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 27
- Engine displacement
- 2.0 L
- Cylinders
- 4
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 24
- Engine displacement
- 2.0 L
- Cylinders
- 4
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 24
- Engine displacement
- 2.0 L
- Cylinders
- 4
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 2.0 L
- Cylinders
- 4
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 2.0 L
- Cylinders
- 4
4-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 23
- Combined MPG on E85
- 17
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 23
- Combined MPG on E85
- 17
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 22
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 23
- Combined MPG on E85
- 18
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 22
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 22
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline or E85 · Midsize Cars
- Combined MPG on premium gasoline
- 22
- Combined MPG on E85
- 16
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 22
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 19
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel Drive · Automatic 7-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 19
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 18
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 18
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 19
- Engine displacement
- 3.5 L
- Cylinders
- 6
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 19
- Engine displacement
- 3.5 L
- Cylinders
- 6