Mercedes-Benz
E450 4matic
U.S. fuel economy and specifications from the EPA.
26Best combined MPG2021 model year
2019–2027Model years9 with EPA ratings
9Rated configurationsDrive, transmission and engine
3 LEngine sizeDisplacement
Best combined MPG by model year
The highest EPA rating among each year's configurations.
2019 23 MPG
2020 23 MPG
2021 26 MPG
2022 25 MPG
2023 26 MPG
2024 25 MPG
2025 25 MPG
2026 25 MPG
2027 25 MPG
1 configuration.
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 3.0 L
- Cylinders
- 6
2025 EPA test-car reference
Engine ratings from the EPA test-car reference.
| Engine rated hp | Displacement | Transmission | Drive |
|---|---|---|---|
| 375 | 3.0 L | Automatic · 9 gears | All Wheel Drive |
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 26
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 25
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 26
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Cars
- Combined MPG
- 23
- Engine displacement
- 3.0 L
- Cylinders
- 6