Mercedes-Benz
E450 4matic (station wagon)
U.S. fuel economy and specifications from the EPA.

22Best combined MPG2019 model year
2019–2020Model years2 with EPA ratings
2Rated configurationsDrive, transmission and engine
3 LEngine sizeDisplacement
Best combined MPG by model year
The highest EPA rating among each year's configurations.
2019 22 MPG
2020 22 MPG
1 configuration.
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Station Wagons
- Combined MPG
- 22
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Midsize Station Wagons
- Combined MPG
- 22
- Engine displacement
- 3.0 L
- Cylinders
- 6