Mercedes-Benz
GLS450 4matic
U.S. fuel economy and specifications from the EPA.

Best combined MPG by model year
The highest EPA rating among each year's configurations.
1 configuration.
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 21
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 21
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 21
- Engine displacement
- 3.0 L
- Cylinders
- 6
2025 EPA test-car reference
Engine ratings from the EPA test-car reference.
| Engine rated hp | Displacement | Transmission | Drive |
|---|---|---|---|
| 375 | 3.0 L | Automatic · 9 gears | All Wheel Drive |
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 21
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 20
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 20
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 21
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 21
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 18
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 19
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 19
- Engine displacement
- 3.0 L
- Cylinders
- 6