Mercedes-Benz
GLS580 4matic
U.S. fuel economy and specifications from the EPA.

18Best combined MPG2020 model year
2020–2026Model years7 with EPA ratings
7Rated configurationsDrive, transmission and engine
4 LEngine sizeDisplacement
Best combined MPG by model year
The highest EPA rating among each year's configurations.
2020 18 MPG
2021 18 MPG
2022 18 MPG
2023 18 MPG
2024 16 MPG
2025 16 MPG
2026 16 MPG
1 configuration.
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 16
- Engine displacement
- 4.0 L
- Cylinders
- 8
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 16
- Engine displacement
- 4.0 L
- Cylinders
- 8
2025 EPA test-car reference
Engine ratings from the EPA test-car reference.
| Engine rated hp | Displacement | Transmission | Drive |
|---|---|---|---|
| 510 | 4.0 L | Automatic · 9 gears | All Wheel Drive |
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 16
- Engine displacement
- 4.0 L
- Cylinders
- 8
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 18
- Engine displacement
- 4.0 L
- Cylinders
- 8
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 18
- Engine displacement
- 4.0 L
- Cylinders
- 8
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 18
- Engine displacement
- 4.0 L
- Cylinders
- 8
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Standard Sport Utility Vehicle 4WD
- Combined MPG
- 18
- Engine displacement
- 4.0 L
- Cylinders
- 8