Mercedes-Benz
S350
U.S. fuel economy and specifications from the EPA.

21Best combined MPG1995 model year
1995–2006Model years2 with EPA ratings
2Rated configurationsDrive, transmission and engine
3.5–3.7 LEngine sizeDisplacement
Best combined MPG by model year
The highest EPA rating among each year's configurations.
1995 21 MPG
1996 No rating
1997 No rating
1998 No rating
1999 No rating
2000 No rating
2001 No rating
2002 No rating
2003 No rating
2004 No rating
2005 No rating
2006 18 MPG
1 configuration.
Rear-Wheel Drive · Automatic 5-spd
Premium gasoline · Large Cars
- Combined MPG
- 18
- Engine displacement
- 3.7 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 4-spd
Diesel · Large Cars
- Combined MPG
- 21
- Engine displacement
- 3.5 L
- Cylinders
- 6