Mercedes-Benz
S400 Hybrid
U.S. fuel economy and specifications from the EPA.

21Best combined MPG2010 model year
2010–2013Model years4 with EPA ratings
4Rated configurationsDrive, transmission and engine
3.5 LEngine sizeDisplacement
Best combined MPG by model year
The highest EPA rating among each year's configurations.
2010 21 MPG
2011 21 MPG
2012 21 MPG
2013 21 MPG
1 configuration.
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Large Cars
- Combined MPG
- 21
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Large Cars
- Combined MPG
- 21
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Large Cars
- Combined MPG
- 21
- Engine displacement
- 3.5 L
- Cylinders
- 6
Rear-Wheel Drive · Automatic 7-spd
Premium gasoline · Large Cars
- Combined MPG
- 21
- Engine displacement
- 3.5 L
- Cylinders
- 6