Mercedes-Benz
S500 4matic
U.S. fuel economy and specifications from the EPA.

24Best combined MPG2021 model year
2003–2027Model years11 with EPA ratings
11Rated configurationsDrive, transmission and engine
3–5 LEngine sizeDisplacement
Best combined MPG by model year
The highest EPA rating among each year's configurations.
2003 16 MPG
2004 16 MPG
2005 16 MPG
2006 16 MPG
2007 No rating
2008 No rating
2009 No rating
2010 No rating
2011 No rating
2012 No rating
2013 No rating
2014 No rating
2015 No rating
2016 No rating
2017 No rating
2018 No rating
2019 No rating
2020 No rating
2021 24 MPG
2022 24 MPG
2023 23 MPG
2024 24 MPG
2025 24 MPG
2026 23 MPG
2027 23 MPG
1 configuration.
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Large Cars
- Combined MPG
- 23
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Large Cars
- Combined MPG
- 23
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Large Cars
- Combined MPG
- 24
- Engine displacement
- 3.0 L
- Cylinders
- 6
2025 EPA test-car reference
Engine ratings from the EPA test-car reference.
| Engine rated hp | Displacement | Transmission | Drive |
|---|---|---|---|
| 443 | 3.0 L | Automatic · 9 gears | All Wheel Drive |
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Large Cars
- Combined MPG
- 24
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Large Cars
- Combined MPG
- 23
- Engine displacement
- 3.0 L
- Cylinders
- 6
All-Wheel Drive · Automatic 9-spd
Premium gasoline · Large Cars
- Combined MPG
- 24
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel Drive · Automatic 9-spd
Premium gasoline · Large Cars
- Combined MPG
- 24
- Engine displacement
- 3.0 L
- Cylinders
- 6
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Large Cars
- Combined MPG
- 16
- Engine displacement
- 5.0 L
- Cylinders
- 8
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Large Cars
- Combined MPG
- 16
- Engine displacement
- 5.0 L
- Cylinders
- 8
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Large Cars
- Combined MPG
- 16
- Engine displacement
- 5.0 L
- Cylinders
- 8
4-Wheel or All-Wheel Drive · Automatic 5-spd
Premium gasoline · Large Cars
- Combined MPG
- 16
- Engine displacement
- 5.0 L
- Cylinders
- 8